MBD3

Proteína 3 con dominio de unión a metil-CpG
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolo	MBD3 (HGNC: 6918)
Identificadores; externos	OMIM: 603573 ; EBI: MBD3; GeneCards: Gen MBD3; UniProt: MBD3;
Locus	Cr. 19 p13.3
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
53615
O95983	n/a
NP_003917	n/a
	v; t; e;
	[editar datos en Wikidata]

La proteína 3 con dominio de unión a metil-CpG (MBD3) es una proteína codificada en humanos por el gen MBD3.^[1]^[2]^[3]

La metilación de ADN es la principal modificación existente en el genoma eucariota y juega un papel crucial en el desarrollo de los mamíferos. Las proteínas humanas MECP2, MBD1, MBD2, MBD3 y MBD4 conforman una familia de proteínas nucleares que se caracterizan por la presencia de un dominio de unión a metil-CpG (MBD). MBD3 es la única incapaz de unirse específicamente al ADN metilado, al contrario de lo que sucede con el resto de sus miembros. La proteína MBD3 comparte un 71% y un 94% de identidad con MBD2 (isoforma 1) y con Mbd3 de ratón, respectivamente. MBD3 es una subunidad de NuRD, un complejo multiproteico con actividad histona deacetilasa y remodelador del nucleosoma. MBD3 media en la asociación de MTA2 con el complejo histona deacetilasa.^[3]

Interacciones

La proteína MBD3 ha demostrado ser capaz de interaccionar con:

Referencias

↑ Hendrich B, Bird A (Nov de 1998). «Identification and characterization of a family of mammalian methyl-CpG binding proteins». Mol Cell Biol 18 (11): 6538-47. PMC 109239. PMID 9774669.
↑ Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A (Sep de 1999). «Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes». Mamm Genome 10 (9): 906-12. PMID 10441743.
↑ ^a ^b «Entrez Gene: MBD3 methyl-CpG binding domain protein 3».
↑ ^a ^b ^c Sakai, Hirotaka; Urano Takeshi, Ookata Kayoko, Kim Mi-Hyun, Hirai Yugo, Saito Motoki, Nojima Yoshihisa, Ishikawa Fuyuki (Dec. de 2002). «MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase». J. Biol. Chem. (United States) 277 (50): 48714-23. ISSN 0021-9258. PMID 12354758. doi:10.1074/jbc.M208461200.
↑ ^a ^b ^c Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug. de 1999). «Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation». Genes Dev. (UNITED STATES) 13 (15): 1924-35. ISSN 0890-9369. PMID 10444591.
↑ ^a ^b Saito, Motoki; Ishikawa Fuyuki (Sep. de 2002). «The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2». J. Biol. Chem. (United States) 277 (38): 35434-9. ISSN 0021-9258. PMID 12124384. doi:10.1074/jbc.M203455200.
↑ Jiang, Chun-Ling; Jin Seung-Gi, Pfeifer Gerd P (Dec. de 2004). «MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex». J. Biol. Chem. (United States) 279 (50): 52456-64. ISSN 0021-9258. PMID 15456747. doi:10.1074/jbc.M409149200.
↑ Brackertz, Marc; Boeke Joern, Zhang Ru, Renkawitz Rainer (Oct. de 2002). «Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3». J. Biol. Chem. (United States) 277 (43): 40958-66. ISSN 0021-9258. PMID 12183469. doi:10.1074/jbc.M207467200.
↑ Feng, Qin; Cao Ru, Xia Li, Erdjument-Bromage Hediye, Tempst Paul, Zhang Yi (Jan. de 2002). «Identification and functional characterization of the p66/p68 components of the MeCP1 complex». Mol. Cell. Biol. (United States) 22 (2): 536-46. ISSN 0270-7306. PMID 11756549.

Datos: Q18040657

[pmid9774669-1] Hendrich B, Bird A (Nov de 1998). «Identification and characterization of a family of mammalian methyl-CpG binding proteins». Mol Cell Biol 18 (11): 6538-47. PMC 109239. PMID 9774669.

[pmid10441743-2] Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A (Sep de 1999). «Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes». Mamm Genome 10 (9): 906-12. PMID 10441743.

[entrez-3] «Entrez Gene: MBD3 methyl-CpG binding domain protein 3».

[pmid12354758-4] Sakai, Hirotaka; Urano Takeshi, Ookata Kayoko, Kim Mi-Hyun, Hirai Yugo, Saito Motoki, Nojima Yoshihisa, Ishikawa Fuyuki (Dec. de 2002). «MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase». J. Biol. Chem. (United States) 277 (50): 48714-23. ISSN 0021-9258. PMID 12354758. doi:10.1074/jbc.M208461200.

[pmid10444591-5] Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug. de 1999). «Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation». Genes Dev. (UNITED STATES) 13 (15): 1924-35. ISSN 0890-9369. PMID 10444591.

[pmid12124384-6] Saito, Motoki; Ishikawa Fuyuki (Sep. de 2002). «The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2». J. Biol. Chem. (United States) 277 (38): 35434-9. ISSN 0021-9258. PMID 12124384. doi:10.1074/jbc.M203455200.

[pmid15456747-7] Jiang, Chun-Ling; Jin Seung-Gi, Pfeifer Gerd P (Dec. de 2004). «MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex». J. Biol. Chem. (United States) 279 (50): 52456-64. ISSN 0021-9258. PMID 15456747. doi:10.1074/jbc.M409149200.

[pmid12183469-8] Brackertz, Marc; Boeke Joern, Zhang Ru, Renkawitz Rainer (Oct. de 2002). «Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3». J. Biol. Chem. (United States) 277 (43): 40958-66. ISSN 0021-9258. PMID 12183469. doi:10.1074/jbc.M207467200.

[pmid11756549-9] Feng, Qin; Cao Ru, Xia Li, Erdjument-Bromage Hediye, Tempst Paul, Zhang Yi (Jan. de 2002). «Identification and functional characterization of the p66/p68 components of the MeCP1 complex». Mol. Cell. Biol. (United States) 22 (2): 536-46. ISSN 0270-7306. PMID 11756549.

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